5 edition of Lipoxygenases and their metabolites found in the catalog.
|Statement||edited by Santosh Nigam and Cecil R. Pace-Asciak.|
|Series||Advances in experimental medicine and biology ;, v. 447|
|Contributions||Pace-Asciak, C., International Symposium on Lipoxygenases and Their Metabolites: Biological Functions (1997 : Malta)|
|LC Classifications||QP603.L56 L57 1999|
|The Physical Object|
|Pagination||ix, 230 p. :|
|Number of Pages||230|
|LC Control Number||98046245|
Fatty acids, especially polyunsaturated, and their metabolites (eicosanoids) play many pivotal roles in human body, influencing various physiological and pathological processes. The aim of the study was to evaluate the effect of supplementation with edible oils diverse in terms of fatty acid composition on fatty acid contents, activities of converting their enzymes, and on lipoxygenase. Plant secondary metabolites can be divided into three chemically distinct groups: terpenes, phenolics, and nitro - gen-containing compounds. FIGURE A shows in sim-plified form the pathways involved in the biosynthesis of secondary metabolites and their interconnections with pri - mary metabolism. In the next three sections of this chapter.
lipoxygenase-catalyzed arachidonic acid metabolism in normal and neoplastic mouse epidermis was assessed by cDNA cloning of the epidermal lipoxygenases and by studying their expression. 12/lipoxygenase (12/LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites.
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis. Prostaglandins Leukot Essent Fatty Acids – Murphy RC, Gijón MA (). Biosynthesis and metabolism of leukotrienes. Biochem J – Radmark O, Samuelsson B (). 5-lipoxygenase: regulation and possible involvement in atherosclerosis. molecular enzymology of lipoxygenase enzymes and their application in the baking industry has been presented. This review, therefore, focuses on the extraction and molecular characterization of lipoxygenases in addition to the work done on the application of lipoxygenases in the baking industry.
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This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a.
This book is a compendium of recent knowledge relating to the biology, pathophysiology, pharmacology, and genetics of lipoxygenases and their products, edited as proceedings of an international congress held in Malta in the summer of It represents state-of-the-art insight into the above topics.
This volume is a compendium of Lipoxygenases and their metabolites book relating to the biology, pathophysiology, pharmacology, and genetics of lipoxygenases and their products, edited as proceedings of an International Congress held in Malta in the summer of This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems.
Lipoxygenases and their metabolites have been indicated as possible mediators in signal transduction pathways and in the regulation of gene expression.
In most of the experiments done so far, different LO inhibitors and LO metabolites have been used in studying the effects of LOs and their reaction products on gene expression. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism.
The Stereochemistry of the Reactions of Lipoxygenases and Their Metabolites. Proposed Nomenclature of Lipoxygenases and Related Enzymes. Hartmut Kühn.
Institute of Biochemistry, Humboldt University, DDR‐ Berlin, GDR Book Editor(s): Alton Meister. Cornell University Medical College, New York, New York. Lipoxygenases have been derived from many plants, mammals and recently also from both eukaryotic and prokaryotic microbes. The best known and characterized lipoxygenases are from soya (Gardner, ).
Soya produces three lipoxygenase isoenzymes, which differ in their biochemical properties (Galliard and Chan, ). Kühn, H., Schewe, T. and Rapoport, S.M. () The stereochemistry of the reaction of lipoxygenases and their metabolites. A proposed nomenclature for lipoxygenases and related enzymes, Adv.
Enzymol – Google Scholar. Lipoxygenases 2. Mammalian Lipoxygenases: Enzymatic Properties and Biological Implications 5 Hartmut Kühn and Sabine Borngräber 3. Molecular Cloning of a Second Human 15S-Lipoxygenase and Its Murin e Homologue, an 8S-Lipoxygenase: Their Relationship to Other Mammalian Lipoxygenases Lipoxygenases and their metabolites in formation of plant stress tolerance.
Babenko LM, Shcherbatiuk MM, Skaterna TD, Kosakivska IV. The review focuses on the analysis of new information concerning molecular enzymology of lipoxygenases – proteins involved in. Kühn H, Banthiya S, van Leyen K () Mammalian lipoxygenases and their biological relevance.
Biochim Biophys Acta (4)– doi: / CrossRef PubMed PubMedCentral Google Scholar. Lipoxygenases and their metabolites in formation of plant stress tolerance Uncategorized No comments L. Babenko 1, M. Shcherbatiuk 1, T. Skaterna 2, I. Kosakivska 1.
Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved in arachidonic acid metabolism.
An increasing number of arachidonic acid metabolites is being discovered and apart from their classically recognized pro-inflammatory effects, anti-inflammatory effects are also being. Lipoxygenases are non-heme dioxygenases of polyunsaturated fatty acids. Their substrates contain a (1Z,4Z)-pentadiene system, which is oxidized to a (1S)-hydroperoxy-(2E,4Z)-pentadiene by lipoxygenases of plants and mammals and to a (1R)-hydroperoxy-(2E,4Z)-pentadiene by lipoxygenases of marine invertebrate ().All known lipoxygenases belong to the same gene family.
Keywords:Lipoxygenase, fatty acid metabolism, protein domains, molecular and cellular signaling, drug development, structure-function relationship.
Abstract: Human lipoxygenases and products of their catalytic reaction have a well established connection to many human diseases. Despite their importance in inflammation, cancer, cardiorenal and.
Sultana C, Shen Y, Rattan V, Kalra VK () Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL cells is linked to protein kinase C activation.
J Cell Physiol (3)– PubMed CrossRef Google Scholar. Effects of and lipoxygenases and their metabolites on renal function and pathology Of importance, the and LOX pathways also act as mediators of the interaction between angiotensin II and aldosterone in the adrenal cortex with important implications on.
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer.
In this article, we aim to provide a brief. Understanding the mechanisms by which lipoxygenase and its metabolites modulate platelet function may lead to the development of a novel class of anti-platelet therapies targeting the enzyme in order to attenuate injury-induced clot formation, vessel occlusion and pathophysiological shifts in.
Abstract. Although the cyclooxygenase (COX) metabolites of arachidonic acid (AA; ; eicosatetraenoic acid) metabolism have received more attention than the metabolites of the lipoxygenases (LOX), there is growing evidence that inhibition of LOX offers an effective means of cancer (and other disease) prevention.Lipoxygenases (LOXs; EC) are nonheme iron-containing dioxygenases widely distributed in plants and animals.
LOX catalyzes the addition of molecular oxygen to polyunsaturated fatty acids containing a (Z, Z)-1,4-pentadiene system to produce an unsaturated fatty acid hydroperoxide.Lipoxygenases (EC ) are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and.